Category: Articles

8 Predictive Biomarkers For Lifetime Health from Dr. Russell Jaffe

Dr. Russell Jaffe was recently interviewed on the Optimal Performance Podcast discussing the top eight predictive biomarkers for lifetime health.

What you’ll learn from Dr. Russell Jaffe on this episode of the Optimal Performance Podcast:

  • The message is: you can control and save your life – or you can put it in the hands of someone else…
  • Genetics = 8%; Epigenetics = 92% of the health that you experience; Epigentics = the lifestyle we live activates, turns on/off certain genes to
  • Predictive Biomarkers = those that have meaning and provides a value around which we can guide therapy
  • Test #1 = Insulin, blood sugar, carbohydrate metabolism = Hemoglobin A1C – measures extra sugar in our body
  • Test #2 = (High Sensitivity) C-Reactive Protein: all-cause morbidity indicator…
  • Test #3 = Homocysteine or HCy: Methylation, repair of blood vessels and cardiovascular health
  • Dr. Jaffe doesn’t care about your MTHFR gene – Clearing up the confusion on 23 & Me, Theranos, the industry buzzword “methylation” and the MTHFR gene
  • Test #4 = Lymphocyte & Immune Tolerance – what environmental compounds can you tolerate without stressing digestion, sleep, mood, cognition, and performance …Basically an ALCAT test on steroids
  • Test #5 = The pH of our first morning urination: Measuring mineral status and cellular metabolic acidosis – the batteries inside the cell for cellular energy
  • Test #6 = Vitamin D (25-HydroxyD): how this “neurohormone” functions in cellular cross-talk and plays a major role in mitigating cellular mutations (Cancer)
  • Rate limiting substrates – or the weak link in your chain
  • Test #7 = The Omega-3:Omega-6 Ratio
  • Test #8 = Oxidative Damage from environmental toxins: How 8-Oxo-Guanine measures exposure to the VOC’s, POPs (hormone disruptors), mold, radiation, chemicals, pesticides, and other landmines from the 21st century
  • The Goldilocks value…not too low, not too high – JUST RIGHT! Knowing the optimal value you want for each of these 8 biomarkers AND how to get there
  • “Eat like a peasant, feel like a King. Eat like a King, die young and suffer.” Old English aphorism
  • How consumers drive change and transition
  • Biodynamic farming and “super organic” plants that produce 2X the
  • Inflammation = repair deficit (physiological term that we are failing to return to baseline)
  • Health Food Superstars “GGOBSE”: Garlic, Ginger, Onions, Brassica, Sprouts, and Eggs
  • “Goal value is to be tolerant to everything. Healthy people are tolerant.”
  • Why Italians laugh at your yellow Olive Oil
  • Addressing oxidative stress with the Vitamin C (ascorbate) cleanse to determine oxidative damage and the link between Vitamin C and auto-immune diseases
  • Where you can find Dr. Russell Jaffe and get more of his work
  • Dr. Jaffe’s Top 3 Tips to #LiveOptimal
  • “Live in harmony with your nature.” (This requires that you know your nature. If you can discover your nature and live in harmony with, THAT is the secret to happiness. Otherwise it is going to fight with you.)

We are what we eat, drink, think and do

The importance of eating and drinking healthy is fairly well understood by most of us. It’s the thinking and doing that often gets left behind. Diet, supplementation, and regular detoxing are important aspects to keeping your body alkaline, healthy, and resilient. Additionally, both mental and emotional health, and general fitness or activity level, significantly impact long-term health, vitality, and resilience.

“Mindfulness meditation,” often recommended as an antidote to the stress and pain of chronic disease, is a practice designed to focus one’s attention intensely on the moment, noting thoughts and feelings as they occur but refraining from judging or acting on those thoughts and feelings. The intent is to deepen awareness of the present, develop skills of focused attention, and cultivate positive emotions such as compassion. According to author Britta Hazel, of Justus Liebig University and Harvard Medical School, the goal of their work was to “unveil the conceptual and mechanistic complexity of mindfulness, providing the big picture by arranging many findings like the pieces of a mosaic.”

With some initial training and guidance and as a part of a daily program, mindfulness can have multiple benefits for health and performance, including improved immune function, reduced blood pressure and enhanced cognitive function.

As one attains a state of concentration, it is due to the four key components of “mindfulness” – the state of meditation – that come together and relieve stress: attention regulationbody awareness, emotion regulation, and sense of self. Understanding the relationships between these components, and the brain mechanisms that underlie them, allows clinicians to better tailor mindfulness interventions for their patients.

We believe the mind and body need to function as a whole, and stress-busting lifestyle practices including meditation form an integral part of the Alkaline Way of living.

Britta K. Hölzel, Sara W. Lazar, Tim Gard, Zev Schuman-Olivier, David R. Vago,Ulrich Ott

How Does Mindfulness Meditation Work? Proposing Mechanisms of Action From a Conceptual and Neural Perspective Perspectives on Psychological Science, November 2011; vol. 6, 6: pp. 537-559.

Britta K. HölzelJames Carmody,Mark VangelChristina Congletonetal.,Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res. 2011 Jan 30; 191(1): 36–43.

This article was first published on PERQUE.

First Line Comprehensive Care Part II:

Anthropogenic Xenobiotics in Functional Medicine.

Managing Persisting Bio-accumulating Pollutants: Toxic Minerals, Biocides, Hormone Mimics, Solvents, and Chemical Disruptors

Russell Jaffe, MD, PhD, CCN, NACB

First line comprehensive care is an increasingly sought choice by patients, clinicians, and frontier scientists, looking functionally for causes; recognizing the role of the integration of mind and body; appreciating our adaptation to our environment; using predictive and provocative labs tests and procedures that are more sensitive, specific, and reliable than usual conventional tests. This article focuses on the approach taken by integrative medicine to manage anthropogenic xenobiotic toxins and clinically useful antitoxin strategies and tactics.

Xenobiotics are biologically active synthetic chemicals, many of which compromise human health. The public health burden due to anthropogenic xenobiotics, which come primarily from toxic minerals (TMs) and persisting organic pollutants (POPs), is an acquired and reversible health tax for over 200 million Americans. According to the Environmental Protection Agency (EPA), over 104,000 synthetic chemicals have been introduced into the environment in the past century. Barely 4,000 (about 4%) have been studied for their toxicities. Only a handful have been studied for their interactions.

The human cost is a reduction of 8.8 years of life for the average person due to the effects of these toxicants. This is a biological tax of 10% of most people’s life span. The direct disease care costs induced by TMs are calculated, in aggregate, to be in excess of $100 billion annually (EPA, 2000; Princeton University, 2001). The public health risk from TMs is even yet greater due to observed but not extensively defined or replicated synergies of mineral toxicities.3 The direct disease care costs induced by POPs are less precisely known yet are about the same cost as TMs. Read more.



First Line Comprehensive Care Part I:

Chronic Autoimmune Disease Management by Causes Rather than Symptomatic Consequences

Russell Jaffe, MD, PhD, CCN, NACB

This article addresses aspects of the human healing response in the context of what the evidence supports in the use of functional assays to improve diagnostic precision, patient-specific comprehensive case management, and out-comes monitoring.

Essential and innate to human life is our immune system, with a principal action in defense and repair. Both defense in response to foreign invaders and repair in response to daily wear and tear are the immune systems primary and required roles for maintenance of human life.

The fundamental approach to first line care articulated herein is based on patient-specific, comprehensive, functional, ex vivo tests and treatment plans. The roles of immune system dysfunction in good health and chronic ill health are explored. Advanced assays that provide comprehensive determination of an individual’s delayed type hypersensitivity (DTH)/delayed allergy reactions are used as examples of how to get to the cause of many chronic “treatment-resistant” issues.

Read more

Predictive Biomarkers

In Personalized Laboratory Diagnosis and Evidence Based Best Practices Outcome Monitoring

Russell Jaffe MD, PhD, CCN, and Jayashree Mani, MS, CCN

Predictive biomarkers are a few tests that can now be referenced to goal values whose interpretation can include a lifestyle action plan that enhances functional cost and outcome effectiveness, adding years to life and life to years.

This article addresses:

  • what these predictive biomarkers are and why they are valid;
  • interpretation of the test results based on goal values;
  • how to reduce risk and bring tests value to or nearer to the safer value at least cost and best outcome effectiveness.

Read more

The Biochemical-Immunology Window:

A Molecular View of Psychiatric Case Management

Russell Jaffe, MD, Ph.D. and Oscar Rogers Kruesi, MD 

Molecular regulation of brain metabolism and function can now be measured selectively. Patients with mood and thought disorders can often be classified based on this information. Clinical management can often be improved by therapeutic interventions based on advanced chemical and immunologic testing techniques. The relevant information is distributed over various medical, laboratory, and research disciplines and, thus, not easily accessible by practicing psychiatrists. This article seeks to bridge this gap. This article focuses on a molecular and cell biology look at the diagnosis and clinical management of the depressions and the schizophrenias.  Read more


Immune Defense and Repair Systems in Biologic Medicine I:

Clinical relevance of biological response modifiers in autoimmunity.

Diagnosis, treatment, tests and interpretation.

By Russell Jaffe, MD, Ph.D.,CCN

A common clinical assumption is that homeostatic mechanisms and immune defense and repair reserves are intact or can be spontaneously restored. This is not the case in autoimmune illnesses where homeostasis and immune defenses have been disrupted as marked by intracellular acidosis, impaired electron transport, and depletion of biochemical cofactors, often concurrently present. The cases and consequences for this are addressed in this article with emphasis on differential diagnosis and recent advances in laboratory testing.  Read more



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