Tag: leaky gut

Gut Hyperpermeability

The gut is a major, potential portal of entry into the body for foreign antigens. Only its intact mucosal barrier protects the body from foreign antigen entry and systemic exposure.

This mucosal barrier is made up of non-immunological components (mucous coat, mucous membranes) working independently and in concert with the local mucosal immune system (secretory IgA, lymphoid elements in Peyer’s patches). Its effective functioning is peripherally assisted by a competent immune system (especially IgA production, RES function), specific hepatobiliary functions (Kupffer cell activation/phagocytosis, hepatocyte function, bile production and elimination), a healthy/balanced population of host-friendly microflora (roughly a 20-40/60-80 ratio of Gram negative to Gram positive with sufficient percent of Lactobacillus species), and optimal digestive processes (adequate HCI/pepsin and pancreatic digestive enzyme activity, optimal soluble fiber intake, low transit time). 

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ALS Supplementation Recommendations

On this episode of “Ask Dr. J”, Dr. Russell Jaffe is asked for recommendations for Amyotrophic Lateral Sclerosis …

EPA/DHA Testing and The Omega-3 Index

In this episode of “Ask Dr. J”, Dr. Russell Jaffe is asked if there is any benefit in testing for EPA or DHA …

Uses of L-Theanine and should we supplement with it?

On this episode of “Ask Dr. J” Dr. Russell Jaffe is asked about the uses of L-Theanine and if we should supplement …