Tag: transit time

Gut Hyperpermeability

The gut is a major, potential portal of entry into the body for foreign antigens. Only its intact mucosal barrier protects the body from foreign antigen entry and systemic exposure.

This mucosal barrier is made up of non-immunological components (mucous coat, mucous membranes) working independently and in concert with the local mucosal immune system (secretory IgA, lymphoid elements in Peyer’s patches). Its effective functioning is peripherally assisted by a competent immune system (especially IgA production, RES function), specific hepatobiliary functions (Kupffer cell activation/phagocytosis, hepatocyte function, bile production and elimination), a healthy/balanced population of host-friendly microflora (roughly a 20-40/60-80 ratio of Gram negative to Gram positive with sufficient percent of Lactobacillus species), and optimal digestive processes (adequate HCI/pepsin and pancreatic digestive enzyme activity, optimal soluble fiber intake, low transit time). 

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Rethinking Inflammation as Repair Deficit

A physiology before pharmacology discussion with Russell Jaffe, MD, PhD, CCN, Sponsored by PERQUE Integrative Health By Natural …

Rethinking Health: Inflammation is Repair Deficit

Inflammation is a familiar term, likely conjuring images of swelling and redness, stiffness and pain. These are certainly …

Explaining the Development of Acquired Immunity Through the Process of Exposure to Antigens

On this edition of “Ask Dr. J”, Dr. Russell Jaffe is asked to explain the development of acquired immunity through …